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Description

J Pharmacol Exp Ther 1995;272:41722.ArticlePubMed 28

documented research protocols reference approximately 200 mcg per dose

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At the physiological phenotype level, CRISPRa has also been used to increase the transcription of obesity risk genes SIM1 and MC4R , and to successfully rescue haploinsufficient obesity in mouse modelswith the effects persisting up to 9 months post-treatment [80]